What is the pericardium and why does it become inflamed?
The pericardium is a dense membrane surrounding the heart and large vessels at their base. It consists of two sheets, between which there is normally about 15–50 milliliters of liquid: this is enough for the sheets to slide without friction. The pericardium anchors the heart in the chest and limits its overextension. With inflammation, the fluid can either be absent altogether - then they talk about dry pericarditis with severe friction and pain - or accumulate in a significant volume, and then the pain usually decreases, but shortness of breath appears.
- Viral infections are the most common cause, especially in young patients
- Bacterial infections, including tuberculous pericarditis, which remains relevant in the region
- Myocardial infarction: inflammation of the pericardium is possible both in the first days and several weeks after it
- Heart surgery and chest trauma
- Autoimmune diseases: systemic lupus erythematosus, rheumatoid arthritis, scleroderma
- Chronic renal failure, especially with insufficient dialysis
- Tumor processes and radiation therapy to the chest area
- Hypothyroidism is a rare but reversible cause of fluid accumulation in the pericardium
In a significant proportion of cases, a specific cause cannot be determined, and such pericarditis is called idiopathic. In practice, this most often means an unrecognized viral infection, and treatment does not change for this. An extensive search for rare causes is not warranted in everyone, but only in cases of prolonged progression, repeated episodes, large volumes of fluid, high fever, or associated symptoms suggestive of systemic disease.
The nature of the pain is the main clue
Pain with pericarditis is most often localized behind the sternum or to the left, and can radiate to the neck, back, left shoulder and, quite characteristically, to the trapezius muscle - the upper edge of the shoulder closer to the neck. But more important than location is how the pain behaves. It is clearly related to breathing and body position, and this connection is so typical that it allows one to suspect the diagnosis even before the examination.
- It gets worse when lying on your back and gets noticeably better when you sit and lean forward.
- Intensifies with a deep breath, when coughing, when swallowing, when turning the body
- Often sharp, stabbing, cutting, and not pressing, as with angina
- Lasts for hours and days, and not 5–15 minutes, like an angina attack
- Not directly related to physical activity: may appear at complete rest
- Often accompanied by low-grade fever and general malaise
- Often occurs one to three weeks after infection
From this picture follows practical advice that is worth remembering: when describing pain to the doctor, be sure to tell what happens when you change body position and when you take a deep breath. The phrases “it’s easier when I sit down and lean forward” and “it hurts more when I take a deep breath” carry more diagnostic information than a detailed description of the intensity of pain on a ten-point scale. At the same time, it is worth noting whether you slept half-sitting, because a forced position is also an important sign.
How to distinguish pericarditis from a heart attack
This is the key question in the first hours, because the tactics for these conditions are fundamentally different. The situation is complicated by the fact that with pericarditis, troponin is also increased - if the inflammation affects the adjacent layer of the heart muscle, and then they talk about myopericarditis. Therefore, the distinction is made based on a set of characteristics, and this is done by the doctor, not the patient.
- Характер и длительность боли: острая, зависящая от положения тела и дыхания, длящаяся часами — в пользу перикардита; давящая, сжимающая, длящаяся 15–30 минут, связанная с нагрузкой — в пользу инфаркта.
- Реакция на положение тела: облегчение сидя с наклоном вперёд для инфаркта нехарактерно.
- Шум трения перикарда при выслушивании — специфичный признак, но он непостоянен и может исчезать через несколько часов.
- ЭКГ: при перикардите изменения обычно распространяются на большинство отведений, тогда как при инфаркте они соответствуют зоне поражённой артерии.
- ЭхоКГ: наличие жидкости в полости перикарда подтверждает диагноз, а нарушение сократимости отдельной стенки указывает скорее на инфаркт.
- Лабораторные показатели: выраженное повышение СРБ характернее для перикардита; значительное и нарастающее повышение тропонина — для инфаркта.
There is only one practical conclusion from this section, and it is more important than all the listed differences: if you have prolonged chest pain, you need to call an ambulance, and not try to figure it out on your own. Even an experienced doctor in some cases cannot distinguish between these conditions without an ECG and tests. Trying to “check” whether bending forward will make it easier, instead of seeking help, is a dangerous waste of time if we are really talking about a heart attack.
Pericardial fluid and cardiac tamponade
During inflammation, fluid can accumulate in the pericardial cavity. What matters is not so much its volume as the rate of accumulation: the pericardium is capable of stretching, but slowly. If the fluid arrives gradually, hundreds of milliliters can accumulate in the cavities without noticeable symptoms. If the accumulation is rapid, even a relatively small volume begins to compress the heart, preventing it from filling with blood. This is tamponade - a condition in which minutes count.
- Increasing shortness of breath, which worsens while lying down and forces you to sit leaning forward
- Severe weakness, dizziness, feeling of impending loss of consciousness
- Drop in blood pressure, rapid and weak pulse
- Swelling of the neck veins with pale, cold and damp skin
- Feeling of tightness and heaviness in the chest, anxiety, restlessness
- Swelling of the face and neck, enlargement of the liver and abdomen with slow accumulation of fluid
- A noticeable weakening of the pulse during inspiration is a sign that a doctor identifies when measuring blood pressure.
Tamponade is an indication for immediate evacuation of fluid under ultrasound guidance, and this procedure quickly and radically improves the condition. That is why, when increasing shortness of breath appears against the background of pericarditis, you cannot wait for a scheduled appointment. Separately, it is worth mentioning the chronic version: with slow accumulation, fluid can be detected by chance on an echocardiogram in a person with minimal complaints. Such a finding does not always require a puncture, but always requires a search for the cause - from hypothyroidism and renal failure to tuberculosis and a tumor process.
Examination and treatment
The diagnosis of acute pericarditis is made by a combination of typical pain, ECG changes, a pericardial friction rub, and the presence of fluid on echocardiography—a few of these signs are sufficient. The treatment of most cases is simple and well-established, and the main mistake of patients here is not in the choice of drug, but in premature cessation of therapy.
- ЭКГ — характерные изменения в большинстве отведений; запись повторяют в динамике, так как картина меняется по стадиям.
- ЭхоКГ — обязательное исследование: выявляет жидкость, оценивает её объём и признаки сдавления сердца.
- СРБ и СОЭ — подтверждают воспаление и служат ориентиром для длительности лечения: терапию продолжают до их нормализации.
- Тропонин — оценивает вовлечение сердечной мышцы; при его повышении режим ограничения нагрузок строже и длительнее.
- Рентген грудной клетки — оценивает лёгкие и тень сердца, помогает заподозрить туберкулёз и другие лёгочные причины.
- Дополнительно при затяжном или повторном течении: обследование на туберкулёз, аутоиммунные маркеры, гормоны щитовидной железы, оценка функции почек, при необходимости КТ или МРТ.
The basis of treatment for acute viral and idiopathic pericarditis is anti-inflammatory drugs in a sufficient dose with a gradual reduction rather than withdrawal immediately after the pain disappears, plus colchicine, which is prescribed over a long course. It is colchicine that significantly reduces the likelihood of relapse, and this is one of the most convincingly proven effects in this area. Glucocorticoids have limited use: they quickly relieve symptoms, but increase the risk of recurrent episodes, so they are prescribed when standard therapy is ineffective or when the disease is autoimmune. Limiting physical activity is a mandatory part of treatment, usually until symptoms disappear and indicators normalize, and for athletes - for a longer period.
Relapses and life after pericarditis
Approximately every fifth patient develops a relapse after the first episode, most often in the first months. This does not mean that the treatment was incorrect or that the disease has become chronic forever: most recurrent pericarditis can be completely controlled over time, although this may require long-term therapy. Knowing a few simple rules significantly reduces the likelihood of a repeat episode.
- Do not stop treatment on your own when the pain disappears - reduce the dose gradually and according to the schedule
- Undergo control tests before ending therapy, and not focus only on how you feel
- Observe the load limit for the entire assigned period; for athletes - before the follow-up examination
- If chest pain returns, contact a cardiologist immediately, rather than wait until it goes away on its own.
- Treat infections in a timely manner and do not carry them on your feet
- If there is a concomitant autoimmune disease, keeping it under control - this directly affects the risk of relapse
- Inform any new doctor about pericarditis: this changes the interpretation of future chest pain and ECG data
A rare but serious long-term complication is constrictive pericarditis, in which the membrane becomes dense, thickened and stops stretching, squeezing the outside of the heart. It develops months and years later, more often after tuberculosis, bacterial or radiation damage, and is manifested by increasing shortness of breath, swelling, enlargement of the abdomen and liver. This condition is treated surgically. With ordinary viral pericarditis, the likelihood of such an outcome is very low, and this is another argument in favor of establishing the cause in a prolonged course, and not limiting ourselves to symptomatic treatment.