Active folates instead of regular ones
For carriers of “slow” MTHFR variants, standard folic acid helps worse - methylfolates with homocysteine control are prescribed: a simple replacement with a measurable effect on pregnancy. The test is a one-time test, interpreted in conjunction with homocysteine (next page), without intimidation by “terrible mutations” - these are frequent controlled polymorphisms.
When is it appointed?
- two or more miscarriages - karyotypes of the couple;
- infertility of unknown origin, severe spermogram abnormalities;
- planning pregnancy with a complicated medical history;
- high homocysteine - genetics of the folate cycle;
- comprehensive pre-gravid preparation.
Genetics of reproduction
Part of pregnancy losses and infertility is recorded in chromosomes and genes: balanced translocations in parents (karyotype), polymorphisms of the folate cycle and thrombophilia affect gestation - and almost all of this is manageable with a known status: from preparation with folates in active form to IVF with preimplantation testing. Genetic tests are taken once in a lifetime and consciously change the couple’s strategy.
