Protective layer of mucous membrane
The glycosaminoglycan layer prevents urine components from irritating the bladder wall and bacteria from attaching to it; its damage underlies interstitial cystitis and frequent relapses of infection. Instilan “re-lines” the mucous membrane: 50 ml of solution is injected through a catheter and held for at least 30–60 minutes. Scheme: weekly 4–6 times, then once every 2–4 weeks up to 6 months; the effect is a reduction in pain, urges and the number of exacerbations in 60–70% of patients. Well tolerated and combined with other treatment methods.
Why are instillations performed?
Instillation is the introduction of a drug directly into the bladder or urethra through a catheter, which creates a high local concentration without systemic action. It is used for chronic and interstitial cystitis, radiation cystitis, chronic urethritis (antiseptics, hyaluronic acid, heparin, drugs for mucosal restoration), as well as in oncourology - intravesical BCG and chemotherapy after TUR of a bladder tumor to prevent relapses.
How it goes
After treating the external opening of the urethra and introducing an anesthetic gel into the bladder, a thin catheter is inserted, residual urine is removed, 20–50 ml of solution is injected, and the catheter is removed. The drug is held for 30 minutes - 2 hours (with BCG - 2 hours, changing position). Course - from 6 to 10 procedures with an interval of 2 days to a week; oncology regimens - 6 weekly induction, then maintenance.
