Phases of chronic B
The classic seroconversion HBeAg→anti-HBe is a favorable turn; however, mutant HBe-negative variants replicate actively with “good” serologies - therefore the triple “anti-HBe + DNA + ALT” always decides. The test is included in a detailed monitoring profile of carriers by a hepatologist.
When is it appointed?
- mandatory block before operations and hospitalization;
- screening after high-risk exposures and procedures;
- elevated ALT/AST – exclusion of viral hepatitis;
- observation and treatment of chronic hepatitis (PCR);
- pregnancy, donation, medical examinations.
Bloodborne infections: test logic
Screening is built in stages: antigens and antibodies (HBsAg, anti-HCV, HIV, RW) detect the fact of infection; PCR tests (HBV DNA, HCV RNA) confirm active replication and measure viral load - the basis of treatment decisions; clarifying markers (HBcore, HBe, delta) detail the phase of hepatitis B. Today hepatitis C can be cured in 8–12 weeks with tablets, B is controlled: early diagnosis literally changes fate. All results are confidential.
