Three sections of the mediastinum and typical tumors
The mediastinum is conventionally divided into three parts, and this division has direct practical significance. In the anterior section, just behind the sternum, tumors of the thymus, lymphomas, substernal goiter and germ cell tumors are most often found. In the middle section, around the trachea and heart, enlarged lymph nodes due to infections and lymphomas, as well as cysts, predominate. In the posterior part, along the spine, tumors of nervous tissue are usually located - in children they are often malignant, in adults they are often benign. Therefore, the first thing the doctor evaluates on a CT scan is the exact localization.
- Anterior mediastinum: thymoma, lymphoma, goiter, germ cell tumors
- Middle mediastinum: lymph nodes and cysts
- Posterior mediastinum: nerve tissue tumors
- Location narrows the range of diagnoses
- Patient age changes probabilities
Symptoms and why they are often absent
The mediastinum is quite spacious, so small formations do not interfere with the functioning of the organs for a long time and do not give rise to complaints. Symptoms appear when the tumor begins to press on neighboring structures. Compression of the trachea and bronchi causes cough and shortness of breath, the esophagus - difficulty swallowing, the recurrent nerve - hoarseness, the sympathetic nerves - drooping eyelids and constriction of the pupil. The most serious is compression of the superior vena cava with swelling of the face, neck and arms, which requires urgent help. Separately, general symptoms are distinguished: fever, sweating and weight loss, characteristic of lymphomas.
- Often asymptomatic
- Cough and shortness of breath due to compression of the airways
- Difficulty swallowing
- Hoarseness of voice
- Drooping of the eyelid and constriction of the pupil
- Swelling of the face and neck due to compression of the superior vena cava
- Fever, sweating and weight loss in lymphomas
Diagnostics
A plain chest x-ray only reveals the expansion of the mediastinal shadow, and the main information is provided by a CT scan with intravenous contrast: it shows the location, density, presence of fat, fluid or calcifications and relationship to the vessels. MRI is particularly useful for posterior mediastinal masses and suspected spinal canal ingrowth. Young men are required to have tumor markers determined to help recognize germ cell tumors. Definitive diagnosis almost always requires obtaining tissue: a biopsy is performed through a CT-guided needle, endoscopically, or surgically.
- Chest X-ray in two projections
- CT chest with contrast
- MRI for posterior mediastinal masses
- Tumor markers in young men
- Thyroid hormones for suspected goiter
- CT-guided biopsy or surgery
- Complete blood count and inflammatory markers
What is not a tumor
Not every mediastinal mass is a neoplasm. Cysts are often found: pericardial, bronchogenic, enterogenic - they have clear contours, liquid contents and usually require only observation. Enlarged lymph nodes occur with tuberculosis, sarcoidosis, fungal and viral infections. A retrosternally located thyroid gland, an aortic aneurysm, or a hiatal hernia can be taken as a shadow of the mediastinum. That is why the decision on treatment is never made based on the image alone, without additional studies.
- Pericardial and bronchogenic cysts
- Enlarged lymph nodes in tuberculosis and sarcoidosis
- Substernal goiter
- Aortic aneurysm
- Hiatal hernia
- Residual thymus tissue in young people
Treatment and observation
Tactics are completely determined by the nature of education. Benign tumors and cysts are removed when they grow, show symptoms or there is doubt about the diagnosis, and many operations today are performed minimally invasively. Lymphomas are treated with chemotherapy and radiation and do not require surgical removal—only a biopsy. Germ cell tumors are sensitive to chemotherapy, after which residual tissue is removed if necessary. Asymptomatic small cysts with a typical appearance are simply observed with repeat CT. It is impossible to independently assess the danger of a find, so consultation with a specialist is important.
- Surgical removal of benign tumors and cysts
- Minimally invasive thoracoscopic surgeries
- Chemotherapy and radiation for lymphomas
- Chemotherapy for germ cell tumors
- Observation for typical asymptomatic cysts
- Repeated CT scan at the appointed time
- Mandatory consultation with a thoracic surgeon or oncologist