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Hepatitis E: how it is transmitted and why it is dangerous during pregnancy

Other names: Гепатит E, вирусный гепатит Е, HEV-инфекция, желтуха от воды, гепатит Е при беременности, острый гепатит Е

Hepatitis E is an acute viral inflammation of the liver, which is transmitted mainly through contaminated water, as well as through insufficiently heat-treated pig and game meat. The disease is common in regions with water supply problems and often causes outbreaks after floods and water supply accidents. In most people, hepatitis E proceeds like ordinary jaundice: weakness, nausea, dark urine, yellowing of the skin, and ends with complete recovery in a few weeks without becoming chronic. However, in pregnant women, especially in the third trimester, the disease can be extremely severe, so they need special vigilance and mandatory medical supervision.

🧾 МКБ-10: B17.2 🏥 Where it is treated: 5 Transmitted through waterUsually goes away on its ownDangerous during pregnancy
👨‍⚕️ Which doctor
Infectious disease specialist, hepatologist, obstetrician-gynecologist during pregnancy
🔬 Diagnostics
Anti-HEV antibodies IgM and IgG, ALT and AST, bilirubin, complete blood count, liver ultrasound
💊 Treatment
Rest, sufficient drinking, gentle nutrition, observation; in severe cases and in pregnant women - hospital
📈 Prognosis
Most make a full recovery in 4–6 weeks; severe course in pregnant women and people with liver diseases
⚠️ At risk
Drinking unboiled water, undercooked meat, traveling to areas with outbreaks, pregnancy, immunodeficiency
⏱ When to see a doctor
Planned; during pregnancy and signs of liver failure - emergency

🚨 See a doctor urgently

With these signs do not wait for a scheduled appointment — the condition requires emergency care.

  • Нарастающая желтуха с сонливостью и спутанностью сознания
  • Кровоточивость дёсен, носовые кровотечения, синяки
  • Многократная рвота, невозможность пить
  • Резкое уменьшение количества мочи
  • Беременность на любом сроке при подозрении на гепатит
  • Ослабленный иммунитет или имеющееся заболевание печени

How the virus is transmitted

The main route is water: the virus enters drinking water sources with wastewater, so outbreaks are associated with water supply failures, floods and the use of water from open reservoirs. The second route is food, through the meat of pigs, wild boar and deer, as well as by-products that have not undergone sufficient heat treatment: these animals are a natural reservoir of the virus. Transmission from person to person through household contacts is rare, unlike hepatitis A. Transmission from mother to fetus is possible and, much less frequently, through blood transfusion.

  • Contaminated drinking water is the main route
  • Undercooked pork and game meat
  • Raw shellfish from polluted waters
  • Unwashed vegetables and fruits washed with contaminated water
  • Transmission from mother to fetus
  • Rarely - through blood products

Symptoms

The incubation period lasts on average from two to six weeks. The disease begins with malaise, weakness, loss of appetite, nausea, heaviness in the right hypochondrium, sometimes with low fever and joint pain. After a few days, the urine darkens, the stool becomes lighter, and yellowness of the sclera and skin appears; With the appearance of jaundice, health usually improves. Itchy skin often bothers me. In many people, especially children, the infection occurs without jaundice and remains unrecognized. Recovery occurs in four to six weeks.

  • Weakness, fatigue, loss of appetite
  • Nausea, sometimes vomiting, heaviness in the right hypochondrium
  • Darkening of urine and lightening of stool
  • Yellowness of the sclera and skin
  • Itchy skin
  • Joint pain and low temperature at the beginning

Why is hepatitis E dangerous during pregnancy?

In pregnant women, especially in the third trimester, hepatitis E is much more severe than in other people and can lead to acute liver failure, bleeding disorders, premature birth and pregnancy loss. The reasons for this severity are associated with changes in immune and hormonal regulation during pregnancy. Therefore, any jaundice in a pregnant woman requires immediate consultation with a doctor and joint management by an infectious disease specialist and an obstetrician-gynecologist, most often in a hospital setting. Self-medication and waiting in this situation are unacceptable.

  • Severe course in the third trimester
  • Risk of acute liver failure
  • Clotting and bleeding disorders
  • Premature birth and pregnancy loss
  • Mandatory hospital observation
  • Joint management by an infectious disease specialist and an obstetrician-gynecologist

Diagnostics

Jaundice and characteristic complaints help to suspect hepatitis; tests confirm this. ALT and AST increase significantly in the blood, bilirubin increases, mainly direct. A specific diagnosis is made by antibodies: the presence of anti-HEV IgM indicates a fresh infection, IgG indicates an advanced or late stage. Be sure to exclude hepatitis A, B and C, as well as drug and toxic liver damage, cholelithiasis and other causes of jaundice. Ultrasound of the liver and gallbladder helps to assess the condition of the organ and exclude a mechanical cause of jaundice.

  • Anti-HEV IgM and IgG antibodies
  • ALT and AST, total and direct bilirubin
  • General blood test
  • Rule out hepatitis A, B and C
  • Ultrasound of the liver and gallbladder
  • Coagulogram in severe cases

Treatment and prevention

Specific antiviral treatment for ordinary acute hepatitis E is not required: the body copes on its own. Prescribe rest, sufficient drinking, gentle nutrition with a limit on fatty and fried foods, avoidance of alcohol and drugs that burden the liver, including many painkillers and herbal remedies. Any medications during this period should be agreed with your doctor. Hospitalization is needed in severe cases, in pregnant women, people with chronic liver diseases and reduced immunity. Prevention comes down to safe water and food: boiling water, thoroughly frying meat, washing hands and food.

  • Rest and adequate drinking
  • Gentle nutrition, avoidance of alcohol
  • Coordinating any medications with your doctor
  • Hospitalization for severe cases and pregnancy
  • Boiling drinking water
  • Thorough heat treatment of meat
  • Washing hands, vegetables and fruits

Services and prices for this diagnosis

Based on official price lists of Tashkent clinics. The exact cost is determined after examination.

Frequently asked questions: Hepatitis E

Does hepatitis E become chronic?+
In people with normal immunity - no, the infection ends with recovery and the formation of immunity. A chronic course is possible in patients with severe immunodeficiency, for example after organ transplantation, and requires special treatment from an infectious disease specialist.
Can you get infected from a sick person?+
The risk is low: unlike hepatitis A, transmission from person to person through normal household contact is rare. The main route is water and food. However, it is wise to practice hand hygiene and not share utensils during illness.
What tests confirm hepatitis E?+
Determination of anti-HEV IgM antibodies indicates a recent infection, anti-HEV IgG indicates a previous infection. Additionally, ALT, AST and bilirubin are assessed and other viral hepatitis must be excluded, since clinically they are very similar.
What can you eat if you have hepatitis E?+
The food is ordinary, but gentle: without alcohol, fatty, fried and spicy foods, with enough liquid, protein and carbohydrates. Severe restrictive diets are unnecessary and even harmful. Dietary supplements and herbal remedies for the liver should not be taken without a doctor’s prescription.
Is there a vaccine against hepatitis E?+
The vaccine has been developed and used in some countries, but is not yet widely used and is not available everywhere. The basis of prevention remains safe drinking water, careful cooking of meat and hygiene.

The information on this page is for reference only and does not replace a doctor consultation. Only a qualified specialist can make a diagnosis and prescribe treatment after an in-person examination.

Where it is treated hepatitis E в Ташкенте

При желтухе и подъёме печёночных ферментов нужно установить причину и исключить другие гепатиты, а беременным — наблюдаться совместно с акушером-гинекологом. Clinics Ташкента с лабораториями и УЗИ печени:

st. Mirzaeva 50, Yunusabad 17, Yunusabad district, Tashkent Landmark: opposite the Nazar M...
M Turkiston 🚶 1.5 km
M Yunusobod 🚶 2.0 km
M Shahriston 🚶 2.8 km
🚌 Nearest bus stop 🚶 100 m · buses: 7
Mon–Fri:09:00–18:00
Open now
Aviasozlar shakharchasi block-4, 6th Aviasozlar passage, Yashnabad district, Tashkent Land...
M Yashnobod 🚶 1.0 km
M Texnopark 🚶 1.2 km
M Tuzel 🚶 1.4 km
🚌 Nearest bus stop 🚶 250 m · buses: 22
Mon–Fri:09:00–17:00
Open now
Tashkent, Yakkasaray district, st. Кичик Халка йули, 26
M Olmazor 🚶 1.2 km
M Chilonzor 🚶 1.7 km
M Mirzo Ulug'bek 🚶 2.5 km
🚌 Nearest bus stop 🚶 220 m · buses: 8, 48
Пн–Sat:09:00–17:00
Open now

ICD-10 code

Official international classification codes — these are used in medical records and statistics.

Other diseases: Infectious diseases

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